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My current research endeavors revolve around the application of micro and nanoscale tools/systems, coupled with cutting-edge optical microscopy techniques, to address complex challenges in biosensors, point-of-care diagnostics, and the mechanics & dynamics of biomolecules and cells. Within my research group, we possess extensive expertise in microfabrication, micropatterning, soft lithography microfluidics, as well as proficiency in brightfield, fluorescence, and superresolution microscopy. Our focus spans cell-material interactions, development & applications of novel sensors and actuators, and the design and implementation of methods, assays, and devices at the micro- and nanoscale.

Some ongoing projects within our research portfolio include:

• Development of portable blood coagulation analysis systems.
• Design and utilization of microfluidic platforms for studying single-cell mechanotransduction.
• Exploration of microfluidic trapping, manipulation, and separation techniques for biomolecules and cells.
• High throughput analysis of single cell behavior.
• Early detection methods for bacteria.

In essence, our multidisciplinary and applied research program centers on the creation of optofluidic tools and techniques to tackle current challenges in the biomedical field. My specific research interests encompass:

• Biomedical microdevices, micro and nanosystems for biology and medicine.
• Microfluidics, bioMEMS/NEMS, in vitro diagnostics, lab-on-a-chip, medical devices, and biosensors.
• Detection and manipulation techniques for biomolecules, cells, and microorganisms.
• Microfabrication, soft lithography, and micropatterning.
• Superresolution imaging and fluorescence spectroscopy.

I adhere to the "educate, inspire, engage" philosophy in my approach to teaching and advising. My primary goal in these roles is to cultivate a positive learning environment that encourages students to acquire, test, and generate knowledge, equipping them with essential skills to emerge as distinguished individuals among the next generation of engineers. As a teacher and mentor, I envision my role as one that kindles students' enthusiasm, stimulates their interest, and ultimately empowers them to think creatively and independently.

Within the domain of Biomedical Engineering, I instruct the following courses under both our undergraduate and graduate programs:

• BMED 110 Introduction to Programming for Engineers
• BMED 310 Biomedical Signals and Systems
• BMED 451/551 Biomedical Microdevices I
• BMED 452/552 Biomedical Microdevices II

Synopsis: 2 book chapters, 20 journal articles, 11 conference proceedings, 4 patents
Web of Science: h-index: 12, total citations: 683, total publications: 32
Scopus: h-index: 13, total citations: 727, total publications: 27
Google Scholar: h-index: 14, total citations: 1054, total publications: 53

Book Chapter:

1. Tanyeri M, and Tay S
鈥淰iable cell culture in PDMS-based microfluidic devices鈥�
Methods in Cell Biology, Volume 148
Microfluidics in Cell Biology Part C: Microfluidics for Cellular and Subcellular Analysis (2018)
Editors: Daniel A. Fletcher, Junsang Doh and Matthieu Piel, ISBN: 978-0-12-814284-4, Elsevier.

2. Tanyeri M, and Schroeder CM
鈥淔low-based particle trapping and manipulation鈥�
Encyclopedia of Microfluidics and Nanofluidics (2014) Article ID: 347830, Chapter ID: 1770 (ed. Dongqing Li), Springer.

Journal:

1. Mustafa A, Ertas Uslu M, and Tanyeri M
鈥淥ptimizing Sensitivity in a Fluid-Structure Interaction-Based Microfluidic Viscometer: A Multiphysics Simulation Study鈥�
Sensors (2023) 23(22), 9265. DOI: https://doi.org/10.3390/s23229265

2. Yang B, Schinke J, Rastegar A, Tanyeri M, and Viator JA
鈥淐ost-Effective Full-Color 3D Dental Imaging Based on Close-Range Photogrammetry鈥�
Bioengineering (2023) 10(11), 1268. DOI: 10.3390/bioengineering10111268

3. Mustafa A, Haider D, Barua A, Tanyeri M, Erten A, and Yalcin O
鈥淢achine learning based microfluidic sensing device for viscosity measurements鈥�
Sensors and Diagnostics (2023) 2, 1509-1520. DOI: 10.1039/d3sd00099k

4. Boyd J, Hepner G, Ujhazy M, Bliss S, and Tanyeri M
鈥淒ual hydrodynamic trap based on coupled stagnation point flows鈥�
Physics of Fluids (2023) 35, 062001. DOI: 10.1063/5.0150089

5. Mustafa A, Eser A, Aksu AC, Kiraz A, Tanyeri M, Erten A, and Yalcin O
鈥淎 micropillar-based microfluidic viscometer for Newtonian and non-Newtonian fluids鈥�
Analytica Chimica Acta (2020) 1135 107-115.

6. Watterson WJ, Tanyeri M, Watson AR, Cham CM, Shan Y, Chang EB, Eren AM, and Tay S
鈥淒roplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes鈥�
eLife (2020) 9:e56998.

7. Evans A, Sutton K, Hernandez S, and Tanyeri M
鈥淰iscoelastic Hemostatic Assays - A Quest for Holy Grail of Coagulation Monitoring in Trauma Care鈥�
Journal of Annals of Bioengineering (2019) 1: 61-64.

8. Mustafa A, Erten A, Ayaz R, Kayillioglu O, Eser A, Irfan M, Muradoglu M, Tanyeri M, and Kiraz A
鈥淓nhanced dissolution of liquid microdroplets in the extensional creeping flow of a hydrodynamic trap鈥�
Langmuir (2016) 32 (37) 9460-9467.

9. Shenoy A, Tanyeri M, and Schroeder CM
鈥淐haracterizing the performance of the hydrodynamic trap using a control-based approach鈥�
Microfluidics and Nanofluidics (2015) 18 (5) 1055-1066.

10. Johnson-Chavarria EM, Agrawal U, Tanyeri M, Kuhlman TE, and Schroeder CM
鈥淎utomated single cell microbioreactor for monitoring intracellular dynamics and cell growth in free solution鈥�
Lab on a Chip (2014) 14 (15) 2688-2697.

11. Marciel AB, Tanyeri M, Wall BD, Tovar JD, Schroeder CM, and Wilson WL
鈥淔luidic-directed assembly of aligned oligopeptides with 蟺-conjugated cores鈥�
Advanced Materials (2013) 25 (44) 6398-6404.

12. Tanyeri M, and Schroeder CM
鈥淢anipulation and confinement of single particles using fluid flow鈥�
Nano Letters (2013) 13 (6) 2357-2364.

13. Kim Y, Kim SH, Tanyeri M, Katzenellenbogen JA, and Schroeder CM
鈥淒endrimer probes for enhanced photostability and localization in fluorescence imaging鈥�
Biophysical Journal (2013) 104 (7) 1566-1575.

14. Tanyeri M, Ranka M, Sittipolkul N, and Schroeder CM
鈥淢icrofluidic Wheatstone bridge for rapid sample analysis鈥�
Lab on a Chip (2011) 11 (24) 4181-4186.

15. Tanyeri M, Ranka M, Sittipolkul N, and Schroeder CM
鈥淎 microfluidic-based hydrodynamic trap: Design and implementation鈥�
Lab on a Chip (2011) 11 (10) 1786-1794.
(selected for the May 23, 2011 issue of Virtual Journal of Nanoscale Science & Technology)

16. Schudel BR, Tanyeri M, Mukherjee A, Schroeder CM, and Kenis PJA
鈥淢ultiplexed detection of nucleic acids in a combinatorial screening chip鈥�
Lab on a Chip (2011) 11 (11) 1916-1923.

17. Johnson-Chavarria EM, Tanyeri M, and Schroeder CM
鈥淎 microfluidic-based hydrodynamic trap for single particles鈥�
Journal of Visualized Experiments (2011) (47) DOI: 10.3791/2517.

18. Tanyeri M, Johnson-Chavarria EM, and Schroeder CM
鈥淗ydrodynamic trap for single particles and cells鈥�
Applied Physics Letters (2010) 96 224101.
(selected for the June 14, 2010 issue of Virtual Journal of Nanoscale Science & Technology)

19. Tanyeri M, and Kennedy IM
鈥淒etecting single bacterial cells through optical resonances in microdroplets鈥�
Sensor Letters (2008) Vol. 6 No. 2 p. 326-329.
(cover article)

20. Tanyeri M, Perron R, and Kennedy IM
鈥淟asing droplets in a microfabricated channel鈥�
Optics Letters (2007) Vol. 32 Issue 17 p. 2529-2531.
(highlighted in photonics.com and Photonics Spectra, October 2007)

Conference Proceedings:

1. Hoying M, Kazimer B, Evans A, Carbino B, Sutton K, McCallin R, and McGee A
鈥淧roject MADMEN: Proposed Analogue Fidelity Comparison to ALIEN Martian Mission鈥�
2022 IEEE Aerospace Conference (AERO) (2022) pp. 01-10, DOI: 10.1109/AERO53065.2022.9843386.

2. Kayillioglu O, Erten A, Tanyeri M, and Kiraz A
鈥淒ye Lasing and Laminar Flow-Induced Dissolution in Hydrodynamically Trapped Oil Microdroplets鈥�
OSA Technical Digest (2015) pp. OtW2D.4 Optical Trapping Applications 2015.

3. Kayillioglu O, Erten A, Kiraz A and Tanyeri M
鈥淗ydrodynamic Trapping of Oil Microdroplets in Glycerol-Water Solution鈥�
Proc. BiyoMUT (2014) BIYOMUT 2014: 18th National Biomedical Engineering Meeting, Istanbul, Turkey.

4. Tanyeri M, and Schroeder CM
鈥淐onfinement and manipulation of single nanoparticles in free solution using a hydrodynamic trap鈥�
Proc. NanoTR (2014) 10th Nanoscience and Nanotechnology Conference, Istanbul, Turkey.

5. Tanyeri M
鈥淐onfinement of single macromolecules in free solution using a hydrodynamic trap鈥�
Proc. SPIE (2014) Vol. 8976 p. 89760F Microfluidics, BioMEMS, and Medical Microsystems XII.

6. Tanyeri M, and Schroeder CM
鈥�2-D micromanipulation of single nanoparticles in free solution using a microfluidic trap鈥�
Proc. MicroTAS (2011) 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences.

7. Schudel BR, Tanyeri M, Schroeder CM, and Kenis PJA
鈥淭otal internal reflection fluorescence of molecular beacons in a multiplexed microfluidic device鈥�
Proc. MicroTAS (2009) Vol. 1 p. 36-38 13th International Conference on Miniaturized Systems for Chemistry and Life
Sciences.

8. Tanyeri M, Perron R, and Kennedy IM
鈥淟asing droplets in a microfluidic T-junction device with integrated optics鈥�
Proc. SPIE (2007) Vol. 6465 p. 64650E Microfluidics, BioMEMS, and Medical Microsystems V.

9. Tanyeri M, Dosev DK, and Kennedy IM
鈥淐hemical and biological sensing through optical resonances in pendant droplets鈥�
Proc. SPIE (2005) Vol. 6008 p. 60080Q Nanosensing: Materials and Devices II.

10. Tanyeri M, Nichkova M, Hammock BD, and Kennedy IM
鈥淐hemical and biological sensing through optical resonances in microcavities鈥�
Proc. SPIE (2005) Vol. 5699 p. 227-236 Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals
and Applications III.

11. Tanyeri M, and Kennedy IM
鈥淢icrodroplets for integrated high-sensitivity biosensors鈥�
Proc. SPIE (2004) Vol. 5275 p. 133-140 BioMEMS and Nanotechnology.

Patents:

1. Tanyeri M, Lin J, Abasiyanik F, Angarita Marmolejo YD
鈥淩apid Enumeration of Microorganisms鈥�
US Application No: 63/184,447 (May 5, 2021), WO 2022/235284 (Nov 10, 2022).

2. Yalcin O, Erten AC, Tanyeri M
鈥淢icrofluidic Thromboelastometry Instrument鈥�
US2021/0268497 (Sep 2, 2021), WO 2020/027741 (Feb 6, 2020), EP3830573 (Jul 29, 2018).

3. Kim Y, Kim SH, Tanyeri M, Katzenellenbogen JA, and Schroeder CM
鈥淒ye-conjugated dendrimers鈥�
US Patent 9,448,173 (September 20 2016).

4. Tanyeri M, Perron R, and Kennedy IM
鈥淥ptical resonances in droplets in a microchannel鈥�
WIPO Publication No: WO 2008/030281 (March 13 2008). International Application No: PCT/US2007/012590.

Presentations
Selected recent presentations are listed below:

Invited:

1. 鈥淢icrofluidic techniques for probing molecular and cellular processes鈥�, 福利免费毛片, Biological Sciences Seminar, Pittsburgh, PA (October 27, 2023)

2. 鈥淢icrofluidic tools for studying biomolecules, cells and soft matter鈥�, Ohio State University, Biophysics Seminar, Columbus, OH (September 29, 2021)

3. 鈥淗ydrodynamic Trap: A new microfluidic tool for studying soft matter鈥�, Carnegie Mellon University, Colloids, Polymers and Surfaces Seminar, Pittsburgh, PA (March 9, 2018)

4. 鈥淥bservation of droplet dissolution in aqueous media using a hydrodynamic trap鈥�, 3rd World Chemistry Conference, Dallas, TX (September 11-12, 2017)


Contributed:


1. Biomedical Engineering Society (BMES) Annual Meeting (poster presentation), 鈥淎 Microfluidic Tweezer for Simultaneous Confinement of a Pair of Cells and Particles鈥�, Jarrett Boyd, Gram Hepner, Maxwell Ujhazy, Shawn Bliss, Melikhan Tanyeri, Seattle, WA (Oct 11-14, 2023)

2. ConnectUR 2023 Annual Conference (oral presentation), 鈥淎 senior-level course in biomedical engineering to develop skills for comprehensive analysis of primary scientific literature and communication of science to the public鈥�, Melikhan Tanyeri, 福利免费毛片 (June 26-28, 2023)

3. Biomedical Engineering Society (BMES) Annual Meeting (poster presentation) 鈥淎pplication of Supervised Machine Learning for Bacteria Analysis in Droplet Microfluidics鈥�, Shawn Bliss, Melikhan Tanyeri, San Antonio, TX (Oct 12-15, 2022)

4. Biomedical Engineering Society (BMES) Annual Meeting (poster presentation) 鈥淧sychLight: a Genetically Encoded Fluorescent Sensor for Drug Discovery鈥� Caroline Daggett, Asef Faruk, Jane Cavanaugh, Kevin Tidgewell, Melikhan Tanyeri, San Antonio, TX (Oct 12-15, 2022)

5. Biomedical Engineering Society (BMES) Annual Meeting (poster presentation) 鈥淎 Microfluidic Viscometer based on Micropillar Deflection and Machine Learning鈥�, Adil Mustafa, Daniyal Haider, Arnab Barua, Melikhan Tanyeri, Ahmet Erten, Ozlem Yalcin, San Antonio, TX (Oct 12-15, 2022)

6. National Conference on Undergraduate Research (NCUR) 2022, 鈥淢icrofluidic-Photoacoustic Flow Cytometry for Diagnosis of Acute Lymphocytic Leukemia鈥�, Shawn Bliss, Melikhan Tanyeri, Virtual, (April 4-8, 2022)

7. Biomedical Engineering Society (BMES) Annual Meeting (oral), 鈥淎 Microfluidic Viscometer towards Real-time, Continuous Measurement of Blood Viscosity鈥�, Melikhan Tanyeri, Adil Mustafa, Ahmet Erten, Ozlem Yalcin, Orlando, FL (Oct 6-9, 2021)

8. American Institute of Chemical Engineers Annual Meeting (oral), 鈥淒ual Hydrodynamic Trap鈥�, San Francisco, CA (November 15-20, 2020)

9. Virtual EMBL Conference: Microfluidics: Designing the Next Wave of Biological Inquiry (poster) 鈥淒ual particle trapping using a microfluidic trap鈥� Presenter: Jarrett Boyd, Virtual/Heidelberg, Germany (July 13-15, 2020)